In the present study, bilayer gastroretentive delivery systems of clarithromycin with aloe vera were successfully developed in the form of hydrodynamically balanced tablets to improve the local action and ultimately its bioavailability. A. vera gel has mucoprotective effect and is also reported to have antiulcer activity. Considering these facts, for clarithromycin and A. vera, the objective of this project work was to design and develop a bilayer floating tablet of Clarithromycin and A. vera gel powder by a direct compression method for the treatment of peptic ulcer. The tablets were formulated using different grades of polymers (HPMC K4M, HPMC K15M and Chitosan) and effervescing agent (NaHCO3). During the formulation, Fourier-transform infrared spectroscopy (FTIR) analysis was performed for possible interactions between drugs and excipients. No interactions between drugs and excipients were noted. Moreover, the bilayer tablets’ thickness, diameter, friability, hardness, weight variation, dissolution and percent purity were found within the acceptable limits. Buoyancy lag time, total floating time, tablet density, Swelling studies showed satisfactory results for batch F1, F2, F3, F5, F6 and F8. The formulation F3 was evaluated for effect of hardness on floating lag time and the results showed that the floating lag time increased as hardness increased due to reduction in porosity. In-vitro dissolution of batch F3 containing HPMC K15M showed good drug release rate in comparison to remaining batches containing chitosan, HPMC K4M, HPMC K10M which were not able to sustain their release up to 10 hrs. Formulations subjected to curve fitting analysis showed to best fit Korsemeyer – Peppas equation and followed non-Fickinian diffusion mechanism. Comparison study with marketed product Clarithro ER showed that the optimized formulation F3 has better control over release rate in comparison with the marketed product.
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